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Intravenous teicoplanin does not prevent Clostridium difficile associated diarrhea
C Wenisch1, E Etzersdorfer, S Breyer
1Abteilung für Infektionen, Universitätsklinik Wien, Austria.
The Clinical Investigator
|November 1, 1994
Summary
Parenteral teicoplanin did not prevent Clostridium difficile-associated diarrhea in an endocarditis patient. Oral teicoplanin effectively treated the diarrhea, suggesting it is a viable option when oral administration is possible.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Background:
- Endocarditis caused by Streptococcus mitis requires effective antibiotic treatment.
- Clindamycin and parenteral teicoplanin were administered to a patient with mitral valve endocarditis.
- Clostridium difficile-associated diarrhea (CDAD) is a potential complication of antibiotic therapy.
Observation:
- A patient developed severe diarrhea and tested positive for Clostridium difficile toxin during parenteral teicoplanin treatment for endocarditis.
- The patient had a history of clindamycin treatment prior to teicoplanin therapy.
Findings:
- Concurrent oral teicoplanin administration led to symptom resolution and negative C. difficile toxin tests.
- Oral teicoplanin effectively cleared C. difficile infection for up to 60 days post-treatment.
- Parenteral teicoplanin did not prevent CDAD in this patient, despite prior clindamycin treatment.
Implications:
- Oral teicoplanin appears to be an effective treatment for CDAD when oral administration is feasible.
- Parenteral teicoplanin is not recommended for treating CDAD, especially in patients with prior clindamycin exposure.
- This case highlights the importance of considering CDAD in patients receiving antibiotics and the potential role of oral teicoplanin in its management.