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Related Experiment Videos

Cognitive impairment--is it inevitable?

C D Binnie1

  • 1Maudsley Hospital, London, UK.

Seizure
|December 1, 1994
PubMed
Summary
This summary is machine-generated.

Neuropsychological dysfunction in epilepsy can stem from subclinical discharges and medication. Lamotrigine effectively controls seizures and subclinical discharges without cognitive impairment, offering a potential treatment benefit.

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Area of Science:

  • Neurology
  • Neuropsychology
  • Pharmacology

Background:

  • Epilepsy frequently causes neuropsychological dysfunction in children and adults.
  • Potential causes include pathophysiology, cerebral pathology, subclinical discharges, sleep disorders, status epilepticus, and drug therapy.
  • Subclinical epileptiform discharges and medication effects are key potentially remediable factors.

Purpose of the Study:

  • To investigate the impact of subclinical epileptiform discharges and antiepileptic drugs on neuropsychological function in epilepsy.
  • To identify antiepileptic drugs that manage seizures and discharges without cognitive side effects.

Main Methods:

  • Review of existing literature on neuropsychological dysfunction in epilepsy.
  • Analysis of the effects of subclinical epileptiform discharges on cognition.

Related Experiment Videos

  • Evaluation of the cognitive impact of various antiepileptic drugs, including phenobarbitone, phenytoin, benzodiazepines, and lamotrigine.

    • Main Results:

    • Subclinical epileptiform EEG discharges are associated with cognitive impairment in up to 50% of patients.
    • Focal discharges typically cause deficits corresponding to the affected brain region's function.
    • Phenobarbitone and phenytoin are evidenced to cause cognitive impairment; benzodiazepines also adversely affect cognition.
    • Most antiepileptic drugs do not suppress inter-ictal discharges, unlike lamotrigine.

    Conclusions:

    • Lamotrigine effectively controls both overt and subclinical seizures without adverse cognitive effects.
    • Antiepileptic drugs that manage both seizures and inter-ictal discharges, without a cognitive penalty, are expected to improve cognitive function.
    • Targeting subclinical discharges and selecting appropriate medications like lamotrigine are crucial for managing neuropsychological dysfunction in epilepsy.