Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lamotrigine--a clinical overview

S J Wallace1

  • 1University Hospital of Wales, Heath Park, Cardiff, UK.

Seizure
|December 1, 1994
PubMed
Summary

Lamotrigine effectively reduced seizures by over 50% in more than 30% of children with refractory epilepsy. This epilepsy medication was well-tolerated, with global improvement noted in 74% of young patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"The most important thing is having patience, both of us." Successful conversations from the perspective of people with aphasia and their primary conversation partners.

Disability and rehabilitation·2025
Same author

Multimodal decoding of human liver regeneration.

Nature·2024
Same author

COS-Speech: protocol to develop a core outcome set for dysarthria after stroke for use in clinical practice and research.

Trials·2023
Same author

Exploring dimensions of quality-of-life in survivors of stroke with communication disabilities - a brief report.

Topics in stroke rehabilitation·2022
Same author

Structural and functional spatial dynamics of microbial communities in aerated and non-aerated horizontal flow treatment wetlands.

The Science of the total environment·2022
Same author

Polycyclic aromatic compounds (PACs) in the Canadian environment: The challenges of ecological risk assessments.

Environmental pollution (Barking, Essex : 1987)·2020

Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology
  • Epileptology

Background:

  • Refractory epilepsy in children presents significant treatment challenges.
  • Limited data exists on lamotrigine's efficacy and tolerability in pediatric populations.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of lamotrigine as add-on therapy in children with refractory epilepsy.
  • To assess long-term efficacy and potential tolerance development.

Main Methods:

  • Pooled data from five identical protocols involving 285 children with refractory epilepsy.
  • Open-label, add-on lamotrigine therapy assessed over 12 weeks of maintenance dosage.
  • Review of smaller trials to confirm findings.

Main Results:

  • Over 30% of patients achieved >50% seizure reduction across various epilepsy types.
  • Investigator and parent evaluations showed global improvement in 74% of children.
  • Lamotrigine was well-tolerated, with rash being the most common side effect (7.4% withdrawal), reduced by slow titration.

Conclusions:

  • Lamotrigine demonstrates a broad spectrum of efficacy in pediatric refractory epilepsy.
  • The drug is well-tolerated in children, with a favorable side effect profile compared to adults.
  • No evidence of tolerance development was observed in children treated for over a year.

Related Experiment Videos