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Short-term intensive 5-fluorouracil treatment of actinic keratoses
1Department of Medicine, University of Florida, Fort Lauderdale, USA.
Background:
5-Fluorouracil therapy is an efficacious treatment for actinic keratoses. However, the prolonged courses of therapy traditionally prescribed are unpleasant, uncomfortable, and can lead to noncompliance.
Objective:
To treat patients with shorter courses of 5-fluorouracil therapy.
Methods:
5-Fluorouracil cream or solution is applied four times daily for periods varying between 7 and 21 days, depending upon the body location.
Results:
The same brisk inflammatory reaction and clearing of the majority of actinic keratoses associated with longer courses of application twice daily is realized.
Conclusion:
5-Fluorouracil can be applied four times daily for shorter periods of time, resulting in clearing of actinic keratoses and patient acceptability.