Related Experiment Video
Updated: Aug 10, 2026

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
Published on: August 3, 2011
Heterologous mesenchymal proliferation of the skin
1Department of Pathology, Children's Hospital, Boston, Massachusetts, USA.
Background:
A benign cutaneous mesenchymal lesion with features of dermatofibroma, dermatomyofibroma, and lipoma is described.
Objective:
An attempt is made to classify this previously undescribed entity.
Methods:
Tissue sections were studied with routine hematoxylin and eosin and a battery of immunoreactants to ascertain the nature of the cells within the lesion.
Results:
The lesion described has a unique histologic appearance, containing elements of mature adipose tissue, smooth muscle, and fibrous tissue.
Conclusion:
Our findings suggest that this tumor is a distinct entity that is not exactly like any previously described lesion and we have given it a descriptive name.
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