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Darier's disease associated with basal cell carcinomas
F Russo1, A Perez-Bernal, F Camacho
1Department of Medical Surgical Dermatology and Venereology, University of Seville School of Medicine, Spain.
Summary
This report details the fourth case of basal cell carcinoma (BCC) in Darier's disease. Oral retinoids revealed hidden BCCs, suggesting early tumor excision is crucial.
Area of Science:
- Dermatology
- Oncology
Background:
- Darier's disease is a rare genodermatosis.
- Basal cell carcinomas (BCCs) are uncommon in Darier's disease, with only three prior cases reported.
Observation:
- The fourth case of BCC occurring in a patient with Darier's disease is presented.
- Oral retinoid therapy was administered for Darier's disease.
Findings:
- Treatment with oral retinoids unmasked additional BCCs within the keratotic papules characteristic of Darier's disease.
- This highlights the potential for BCC to be obscured by Darier's disease lesions.
Implications:
- Early detection and surgical excision of BCC in patients with Darier's disease may be facilitated by therapies that reduce keratotic lesions.
- Understanding the pathogenetic link between Darier's disease and BCC is important for patient management.