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Reduction of baroreceptor-related sympathetic discharge during NMDA receptor antagonism
1Department of Pediatrics, Schneider Children's Hospital, Albert Einstein College of Medicine, New Hyde Park, NY 11042.
Brain Research
|December 5, 1994
Abstract:
N-Methyl-D-aspartate receptor blockade by MK-801 produced changes in the baroreceptor related component of pre-ganglionic sympathetic discharges in kittens. Spectral analyses carried out on sympathetic and blood pressure signals demonstrated: (a) a marked reduction in amplitude of peaks, 2-6 Hz range, in sympathetic autopower spectra and (b) a substantial decrease of coherence between sympathetic and blood pressure signals in the 2-6 Hz range.