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Updated: Oct 9, 2026
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Published on: September 21, 2021
Induction of muricidal behavior by ACTH or adrenalectomy in young male Wistar rats
S Miachon1, B Claustrat, R Cespuglio
1Laboratoire de Neurochimie Fonctionnelle, INSERM U 171 et U 52, CNRS URA 1195, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
Abstract:
ACTH administered IP induces a muricidal behavior in 52% of male Wistar rats that do not express it before; such behavior is also observed spontaneously in 68% of adrenalectomized animals. This change in behavior is characterized by an exceptionally long duration (several months in some animals), and by its prevention by previous or substitutive treatments with dexamethasone. Data obtained using hypophysectomized or adrenalectomized animals with or without ACTH treatments suggest that the muricidal-inducing effect of ACTH might have, at least partially, a central origin.
