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Related Experiment Videos

Optical microscopy. 3. Tracking fluorescently labeled neurons in developing brain

G Fishell1, R Blazeski, P Godement

  • 1Laboratory of Developmental Neurobiology, Rockefeller University, New York, New York 10021.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|March 1, 1995
PubMed
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Time-lapse microscopy now offers dynamic views of developing nervous tissue, tracking neuron migration and axonal navigation. This technique provides firsthand documentation of developmental patterning in living brain tissue.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Microscopy

Background:

  • Time-lapse microscopy has long been used for biological phenomena.
  • Previous studies of the developing nervous system were limited to cell cultures or static images.
  • Advancements in fluorescent dyes and video imaging have enabled new insights.

Purpose of the Study:

  • To explore novel views of neuron behavior in developing nervous tissue.
  • To document dynamic events like cell migration and axonal navigation.
  • To establish video time-lapse microscopy as an experimental assay for developmental patterning.

Main Methods:

  • Utilizing advanced fluorescent dyes and video imaging technology.
  • Observing neuron behavior in the context of developing nervous tissue.

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  • Combining time-lapse monitoring with post-fixation techniques like immunocytochemistry and electron microscopy.

    • Main Results:

    • Novel views of neuron migrations within and away from proliferative zones.
    • Detailed observation of axonal process navigation to synaptic targets.
    • Firsthand documentation of developmental patterning in living brain tissue.

    Conclusions:

    • Video time-lapse microscopy provides unprecedented views of neural development.
    • This technique allows for the study of individual cell behaviors and interactions.
    • It serves as a powerful experimental assay for understanding developmental patterning.