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Urinary calcium creatinine ratio and hypercalciuria

B Rath1, M K Aggarwal, T K Mishra

  • 1Department of Pediatrics, Maulana Azad Medical College, New Delhi.

Indian Pediatrics
|March 1, 1994
PubMed
Summary

This study investigated urinary calcium-creatinine ratio (Uca/Ucr) in children aged 5-12 years. The research found a 6.5% prevalence of hypercalciuria in the general pediatric population, independent of age or sex.

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Area of Science:

  • Pediatric Nephrology
  • Clinical Chemistry

Background:

  • Hypercalciuria in children can indicate underlying renal or metabolic conditions.
  • Establishing normative data for urinary calcium-creatinine ratio (Uca/Ucr) is crucial for accurate diagnosis in pediatric populations.

Purpose of the Study:

  • To determine the prevalence of hypercalciuria in a general pediatric population.
  • To establish the normal range for urinary calcium-creatinine ratio (Uca/Ucr) in children aged 5-12 years.
  • To assess the relationship between Uca/Ucr, age, and sex in children.

Main Methods:

  • Analysis of random urine samples from 352 children (5-12 years old) without predisposing factors for secondary hypercalciuria.
  • Quantification of urinary calcium and creatinine using a colorimetric method.

Related Experiment Videos

  • Calculation of the urinary calcium-creatinine ratio (Uca/Ucr) and statistical analysis to determine the upper limit of normal and prevalence.

    • Main Results:

    • The distribution of Uca/Ucr in the studied pediatric cohort was skewed, mirroring patterns observed in Western children.
    • The mean Uca/Ucr was 0.10 with a standard deviation of 0.094.
    • Hypercalciuria (defined as Uca/Ucr > 0.29, mean + 2SD) was identified in 6.5% of the children, with no significant association with age or sex.

    Conclusions:

    • The study establishes a reference range for Uca/Ucr in children aged 5-12 years.
    • A 6.5% prevalence of hypercalciuria was observed in the general pediatric population, suggesting a need for awareness.
    • Urinary calcium-creatinine ratio is a valuable screening tool for hypercalciuria in children, independent of age and sex.