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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
A model for the nutritional transport in capillary-tissue exchange system
P N Tandon1, M Misra, A Chaurasia
1Department of Mathematics, University Brunei Darussalam.
International Journal of Bio-Medical Computing
|September 1, 1994
Summary
This study analyzes plasma flow and nutrient transport in blood vessels. In diseased states, reduced nutrient penetration causes cell death in deeper tissues.
Area of Science:
- Biomedical Engineering
- Fluid Dynamics
- Physiology
Background:
- Understanding nutrient transport in microcirculation is crucial for tissue health.
- Diseases can impair blood flow and nutrient delivery to tissues.
Purpose of the Study:
- To analyze plasma flow and nutrient transport between cells and vessel walls.
- To investigate the impact of diseased states on nutrient penetration and tissue survival.
Main Methods:
- Applied lubrication theory to model squeezing flow of plasma.
- Assumed single-file, axi-symmetric cell flow within the vessel.
- Modeled nutrient concentration profiles considering bolus flow between cells.
Main Results:
- Plasma flow and nutrient transport dynamics were analyzed.
- Nutrient concentration profiles within the tissue were determined.
- In diseased states, a reduced penetration depth of substances was observed.
Conclusions:
- Impaired nutrient delivery in diseased states affects deeper tissue cells.
- Cells in deeper regions may not receive adequate nutrition, leading to cell death.
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