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Forearm compression during exercise increases sympathetic nerve traffic

J McClain1, J C Hardy, L I Sinoway

  • 1Division of Cardiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|December 1, 1994
PubMed
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Forearm compression at 110 mmHg augmented muscle sympathetic nerve activity (MSNA) during static exercise, suggesting it sensitizes mechanoreceptors. This increased pressure likely enhances nerve responses, contributing to greater sympathoexcitation.

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Regulation

Background:

  • Forearm venous congestion previously augmented muscle sympathetic nerve activity (MSNA) during static exercise.
  • This augmentation was hypothesized to result from increased interstitial pressure sensitizing mechanoreceptor afferents, leading to greater sympathoexcitation.

Purpose of the Study:

  • To test the hypothesis that forearm compression (FC) increases interstitial pressure and selectively stimulates mechanically sensitive afferents.
  • To investigate the effect of FC on MSNA and hemodynamic responses during static exercise.

Main Methods:

  • Muscle sympathetic nerve activity (MSNA) was measured during 2-minute static exercise (40% maximal voluntary contraction) and post-exercise circulatory arrest.
  • Exercise was repeated after 5 minutes of FC induced by forearm cuff inflation to 90 mmHg (n=6) and 110 mmHg (n=7).

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Main Results:

  • FC alone did not affect hemodynamic variables.
  • FC at 90 mmHg did not augment exercise-induced MSNA or mean arterial blood pressure responses.
  • FC at 110 mmHg significantly augmented reflex responses during static exercise, increasing MSNA (277±58 to 503±82 arbitrary units, P<0.02) and mean arterial pressure (35±4 to 41±5 mmHg, P<0.003).
  • Post-handgrip circulatory arrest responses were unaffected by FC, suggesting metaboreceptor stimulation was not involved.

Conclusions:

  • Forearm compression at 110 mmHg sensitizes mechanoreceptors, leading to increased sympathoexcitation during static exercise.
  • This finding supports the role of mechanoreceptor activation in exercise pressor reflex modulation.