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Related Experiment Videos

Functional enuresis: is desmopressin the answer?

S Thompson1, J M Rey

  • 1New South Wales Institute of Psychiatry, Australia.

Journal of the American Academy of Child and Adolescent Psychiatry
|March 1, 1995
PubMed
Summary
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Desmopressin effectively treats functional enuresis, reducing wet nights by one-third for frequent bedwetters. While generally safe, potential side effects like seizures warrant further investigation into long-term use.

Area of Science:

  • Psychiatry
  • Pediatrics
  • Pharmacology

Background:

  • Functional enuresis is a common condition with limited psychiatric literature on desmopressin.
  • Desmopressin has been used for 15 years, but its efficacy and safety profile require critical assessment.

Purpose of the Study:

  • To critically evaluate the effectiveness, risks, and side effects of desmopressin for functional enuresis.
  • To explore the implications of desmopressin treatment for understanding and managing enuresis.

Main Methods:

  • Systematic review of treatment trials.
  • Analysis of reported adverse effects.
  • Literature review on desmopressin's mechanism of action.

Main Results:

Related Experiment Videos

  • Desmopressin demonstrates superior efficacy compared to placebo in controlled trials.
  • Approximately 25% of patients achieve complete dryness; others experience a one-third reduction in wet nights.
  • High relapse rates are observed upon treatment cessation; side effects are generally minimal, though hyponatremic seizures are increasingly reported.

    • Conclusions:

    • Desmopressin is a user-friendly and effective treatment for nocturnal enuresis.
    • The drug has stimulated new research directions but requires more data on long-term outcomes and adverse effects.
    • A subset of patients may have enuresis due to insufficient nocturnal vasopressin secretion.