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Elevated serum CA125 in progressive systemic sclerosis with pleural effusion
1Department of Dermatology, School of Medicine, Tokyo Medical and Dental University, Japan.
The Journal of Dermatology
|January 1, 1995
Summary
Elevated CA125 levels were observed in a patient with progressive systemic sclerosis (PSS) and pleuritis, suggesting its potential as an indicator for pleural effusion in collagen diseases.
Area of Science:
- Rheumatology
- Oncology
- Clinical Chemistry
Background:
- Tumor markers, such as CA125 and CA19-9, are increasingly reported in benign conditions like systemic lupus erythematosus (SLE) and rheumatoid arthritis.
- Investigating tumor marker elevation in collagen diseases is crucial for differential diagnosis.
Observation:
- A unique case of a female patient with progressive systemic sclerosis (PSS) and pleuritis presented with significantly elevated serum and pleural effusion levels of CA125.
- Serum CA125 and CA19-9 levels were measured in the PSS patient, 27 other female collagen disease patients (SLE, PSS, dermatomyositis, Sjögren syndrome), and 11 healthy controls.
Findings:
- The PSS patient exhibited markedly high CA125 levels, distinguishing her from normal controls and other collagen disease patients.
- No significant elevation of CA19-9 or CA125 was found in the other collagen disease patients compared to controls, except for the presented PSS case.
Implications:
- Elevated serum CA125 may serve as a specific indicator for pleural effusion in patients with collagen-related diseases, particularly PSS.
- This case highlights the importance of considering non-malignant causes for elevated tumor markers and their potential role in specific rheumatological conditions.