Transient transport across an inhomogeneous blood-retina barrier

A mathematical model for transport across the blood-retina barrier and diffusion into the vitreous body of the human eye is formulated. The eye is modeled as a sphere, the surface of which represents the blood-retina barrier. The equations of the model are solved analytically, using an expansion in spherical harmonics and inversion of the Laplace transform in the time variable. The numerical properties of the solution are investigated and the applicability of the model to the analysis of data from three-dimensional vitreous fluorometry is discussed.