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Identification of human papillomavirus seroconversions
A Wikström1, G J van Doornum, W G Quint
1Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.
The Journal of General Virology
|March 1, 1995
Summary
Antibody responses to human papillomavirus (HPV) are often induced following genital HPV infection. These immune responses can be transient, particularly in men, and show limited type-specificity.
Area of Science:
- Immunology
- Virology
- Public Health
Background:
- The timing of antibody induction after primary genital human papillomavirus (HPV) infection is not well understood.
- Understanding this relationship is crucial for vaccine development and disease management.
Purpose of the Study:
- To investigate the temporal association between genital HPV infection and the development of HPV-specific antibodies.
- To characterize the nature and duration of antibody responses following new HPV infections.
Main Methods:
- A cohort study of 110 women and 48 men with multiple heterosexual partners was conducted.
- Participants provided samples for HPV DNA testing and serological analysis against various HPV antigens.
- Follow-up included 583 clinic visits over 220 person-years.
Main Results:
- Seroconversions were observed in 16/158 patients, with 10/16 being HPV-positive.
- Antibodies, particularly IgG against HPV-16 virus-like particles and E2-derived peptide, were induced during new HPV infections.
- Responses in women tended to increase, while responses in men were often transient.
Conclusions:
- Genital HPV infection frequently triggers antibody responses to multiple viral antigens.
- The observed antibody responses exhibit limited type-specificity.
- Transient immune responses are common following HPV detection.