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Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis
S Roux1, M Grossin, M De Bandt
1Department of Rheumatology, Bichat Hospital, Paris, France.
Journal of Neurology, Neurosurgery, and Psychiatry
|March 1, 1995
Summary
Angiotropic large cell lymphoma (ALCL) can present with unusual symptoms like isolated mononeuritis multiplex and fever. This case highlights ALCL as a crucial differential diagnosis for systemic necrotising vasculitis.
Area of Science:
- Oncology
- Neurology
- Pathology
Background:
- Angiotropic large cell lymphoma (ALCL), also known as malignant angioendotheliomatosis, involves tumor cell proliferation within small blood vessels.
- ALCL commonly affects the central nervous system and skin, but can involve any organ.
- Recent classifications integrate ALCL into large cell lymphomas, influencing therapeutic strategies and potentially improving prognosis.
Observation:
- An unusual case of ALCL presented with fever, mononeuritis multiplex, and cutaneous lesions.
- The patient exhibited peripheral neuropathy without other neurological symptoms.
- This presentation of isolated mononeuritis multiplex with nerve lesions is, to our knowledge, unprecedented in ALCL.
Findings:
- The clinical diagnosis was initially systemic necrotising vasculitis.
- The reported case expands the spectrum of clinical manifestations of ALCL.
- The findings underscore the importance of considering ALCL in the differential diagnosis of vasculitic syndromes.
Implications:
- This case broadens the understanding of ALCL's diverse clinical presentations.
- Recognizing ALCL in vasculitis differentials may lead to earlier diagnosis and treatment.
- Improved diagnostic approaches for ALCL could enhance patient outcomes in this aggressive lymphoma.