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Mammary excretion of cannabidiol in rabbits after intravenous administration
S D Yoo1, T K Fincher, J W Holladay
1Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia 29208.
The Journal of Pharmacy and Pharmacology
|November 1, 1994
Abstract:
The present study examined the distribution of cannabidiol into milk after an intravenous bolus injection (3 mg kg-1) to lactating rabbits. Drug concentrations in milk and serum were measured by HPLC. Cannabidiol was excreted into milk rapidly and the drug levels in milk increased over a 4-24-h period following the maternal injection. The mean milk to serum concentration ratio was 25.9, indicating a significant accumulation of the drug in milk.