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Holoprosencephaly in a long-tailed macaque (Macaca fascicularis): a case report
A F Tarantal1, G Otiang-a-Owiti, A G Hendrickx
1California Regional Primate Research Center, University of California, Davis 95616-8542.
Journal of Medical Primatology
|August 1, 1994
Abstract:
A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.