Histochemical fluorescence studies of brain monoamines in goldthioglucose-treated rabbits

Fluorescence histochemical experiment of brain monoamines and chemical analysis of brain 5-hydroxytryptamine (5-HT) in goldthioglucose (GTG)-treated rabbits were performed. The fluorescence of brain catecholamines (CA) and 5-HT were strengthened in intensity until first week after treatment and reduced from second week. Body weight in GTG-treated rabbits showed decreasing tendency in the period when monoamine fluorescence was strengthened and increased when monoamine fluorescence was lowered in intensity. Content of brain 5-HT second day after treatment showed an increasing tendency in the cortex. In comparison with EEG findings by Matsumura, it is speculated that there is correspondence between slow wave in EEG and increased fluorescence of brain monoamines and between spiky and decreased fluorescence.