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Correlation between [125I]calmodulin binding and lipid fluidity in synaptic plasma membranes: effects of ethanol and
1Department of Pharmacology and Molecular Biology, Chicago Medical School, IL 60064-3095.
Brain Research. Molecular Brain Research
|December 1, 1994
Abstract:
Ethanol inhibits [125I]calmodulin binding to synaptic plasma membranes from rat brain, and this inhibition is correlated in a concentration-dependent manner with the increase of membrane fluidity, as determined by diphenylhexatriene fluorescence polarization. Moreover, several short-chain alcohols that increase membrane fluidity are also effective inhibitors of [125I]calmodulin binding. These data support the notion that ethanol inhibits calmodulin binding by increasing lipid fluidity of the synaptic membranes.