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Beclomethasone dipropionate in long-term treatment of asthma in children
The Journal of Pediatrics
|November 1, 1976
Insights
Beclomethasone dipropionate effectively reduces pediatric asthma symptoms without impacting lung function. Long-term use shows no adverse effects on growth or organ function, though it may increase oral yeast infections.
Area of Science:
- Pediatric Pulmonology
- Clinical Pharmacology
Background:
- Childhood asthma requires effective and safe long-term management strategies.
- Inhaled corticosteroids are a cornerstone of asthma therapy, but safety profiles require ongoing evaluation.
Purpose of the Study:
- To assess the efficacy and safety of beclomethasone dipropionate in pediatric asthma patients.
- To evaluate the long-term effects of beclomethasone dipropionate on pulmonary function, growth, and organ systems.
Main Methods:
- A cohort of pediatric asthma patients received beclomethasone dipropionate at 100 mug three times daily.
- Pulmonary function tests, growth parameters, adrenal function, serum electrolytes, and hepatic/renal functions were monitored over 18 months.
Main Results:
- Beclomethasone dipropionate significantly reduced asthma symptoms.
- No measurable impact on pulmonary function was observed.
- No adverse effects on adrenal function, growth, electrolytes, or hepatic/renal functions were detected over 18 months.
- A predisposition to Candida albicans colonization in the oropharynx was noted.
Conclusions:
- Beclomethasone dipropionate is an effective treatment for pediatric asthma with a favorable 18-month safety profile regarding growth and organ function.
- Healthcare providers should be aware of the potential for oropharyngeal candidiasis with this treatment.
Abstract:
Beclomethasone dipropionate was found to be effective in reducing symptoms of asthma in children. There was no measurable influence on pulmonary function. An 18-month follow-up did not show untoward side effects on adrenal function, growth, serum electrolytes, and hepatic and renal functions with a dose of 100 mug three times daily. The treatment predisposes to the colonization with Candida albicans in the oropharynx.