Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure and function of poly(ADP-ribose) polymerase

G de Murcia1, V Schreiber, M Molinete

  • 1Ecole Supérieure de Biotechnologie de Strasbourg, Unité de Cancérogénèse et de Mutagénèse Moléculaire et Structurale, Centre National de la Recherche Scientifique, Illkirch-Graffenstaden, France.

Molecular and Cellular Biochemistry
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linking emotional valence and anxiety in a mouse insula-amygdala circuit.

Nature communications·2023
Same author

Screening and treatment of Post-Selective Serotonin Reuptake Inhibitors sexual dysfunctions.

L'Encephale·2022
Same author

Creating a new chapter in the DSM for late-onset depressive disorders.

L'Encephale·2022
Same author

Barriers and opportunities for the continuous training of healthcare professionals in the post-Covid era.

L'Encephale·2022
Same author

The neuroinflammatory pathways of post-SARS-CoV-2 psychiatric disorders.

L'Encephale·2021
Same author

Psychotropics and COVID-19: An analysis of safety and prophylaxis.

L'Encephale·2021
Same journal

High glucose-induced mitochondrial fission promotes Müller cell activation via suppression of the Hippo pathway.

Molecular and cellular biochemistry·2026
Same journal

Correction to: Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein.

Molecular and cellular biochemistry·2026
Same journal

Galectin-3, transforming growth factor beta 1, and brain natriuretic peptide in cardiac remodeling under hyperlipidemic and hyperglycemic stress.

Molecular and cellular biochemistry·2026
Same journal

Ellagic acid from the traditional Chinese medicinal herb Scutellaria barbata may accelerates apoptosis in hepatic stellate cells during liver fibrosis via inhibiting miR-182-5p.

Molecular and cellular biochemistry·2026
Same journal

GeneQuantify: a web-based tool for qPCR gene expression and copy number variation analysis.

Molecular and cellular biochemistry·2026
Same journal

NCAPG reprograms glycolytic and lipid metabolism by sustaining glycerophospholipid flux in small-cell lung cancer.

Molecular and cellular biochemistry·2026
See all related articles

Poly(ADP-ribose) polymerase (PARP) is crucial for eukaryotic cells to repair DNA damage from genotoxic agents. Cloning the PARP gene enables genetic studies of this enzyme's structure and function.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Eukaryotic cells possess complex systems to counteract DNA damage.
  • Poly(ADP-ribose) polymerase (PARP) is a key enzyme involved in DNA repair pathways.
  • Environmental and endogenous factors can cause genotoxic stress.

Purpose of the Study:

  • To summarize current knowledge on the structure and function of PARP.
  • To highlight the impact of PARP gene cloning on research.
  • To provide an overview of genetic and molecular approaches to study PARP.

Main Methods:

  • Review of existing literature on PARP.
  • Analysis of genetic and molecular studies following PARP gene cloning.
  • Synthesis of information regarding PARP enzyme structure and function.

Related Experiment Videos

Main Results:

  • PARP is an abundant and highly conserved enzyme in eukaryotes.
  • Gene cloning has facilitated detailed investigation of PARP.
  • Significant progress has been made in understanding PARP's role in DNA repair.

Conclusions:

  • PARP plays a vital role in cellular responses to DNA damage.
  • The cloning of the PARP gene has revolutionized its study.
  • Further research continues to elucidate the intricate functions of PARP.