Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Poly(ADP-ribose): historical perspective

T Sugimura¹, M Miwa

¹National Cancer Center, Tokyo, Japan.

Molecular and Cellular Biochemistry

|September 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dipole Strength Distribution of ^{8}He and Decay Characteristics.

Physical review letters·2026

Same author

Evaluation of eustachian tube function using a portable device.

JASA express letters·2022

Same author

Polymorphism of simple sequence repeats reveals gene flow within and between ectomycorrhizal Suillus grevillei populations.

The New phytologist·2021

Same author

Neutron-induced signal on the single crystal chemical vapor deposition diamond-based neutral particle analyzer.

The Review of scientific instruments·2020

Same author

Neurokinin 3 receptor-selective agonist, senktide, decreases core temperature in Japanese Black cattle.

Domestic animal endocrinology·2020

Same author

Design optimization of a fast-neutron detector with scintillating fibers for triton burnup experiments at fusion experimental devices.

The Review of scientific instruments·2019

Same journal

Bile acid-induced TBG depletion promotes trophoblast apoptosis via local thyroxine insufficiency in intrahepatic cholestasis of pregnancy.

Molecular and cellular biochemistry·2026

Same journal

The factors between BMI and diabetic nephropathy and protective role of the FGF21-SIRT1 axis in diabetic nephropathy.

Molecular and cellular biochemistry·2026

Same journal

Naringenin inhibits endothelial-mesenchymal transition and alleviates myocardial fibrosis in rats by regulating the AKT/GSK3β/β-catenin pathway.

Molecular and cellular biochemistry·2026

Same journal

P2Y12-AMPKα2 signaling contributes to cardiomyocyte senescence in doxorubicin-induced heart failure.

Molecular and cellular biochemistry·2026

Same journal

Synthesis and multilevel evaluation of benzimidazole-based anticancer compounds: DNA/serum albumin interaction, and in-depth theoretical insights.

Molecular and cellular biochemistry·2026

Same journal

Hijacking the cytoskeleton: association of HCV polymerase with α/β-tubulin and its potential relation to the viral replication and cell proliferation.

Molecular and cellular biochemistry·2026

See all related articles

This review covers the discovery and development of poly(ADP-ribose) (PAR) science. It summarizes fundamental knowledge on PAR, its synthesis, and degradation, and discusses future research directions.

Area of Science:

Biochemistry
Molecular Biology
Genetics

Background:

The historical discovery and scientific evolution of poly(ADP-ribose) (PAR) are detailed.
Fundamental aspects of PAR, including its synthesis and degradation pathways, are presented.

Observation:

Key enzymes involved in poly(ADP-ribose) metabolism, such as poly(ADP-ribose) polymerase (PARP), are described.
Methodologies for the purification and characterization of PAR and related enzymes are summarized.

Findings:

This review consolidates foundational knowledge on poly(ADP-ribose) and its associated enzymatic machinery.
It provides a comprehensive overview of the current understanding of PAR biology.

Implications:

Related Experiment Videos

Future research avenues focusing on the biological significance of poly(ADP-ribose) are briefly explored.

This work serves as a foundational resource for researchers entering the field of PAR biology.