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Serotonin and bulimia nervosa

T E Weltzin1, M H Fernstrom, W H Kaye

  • 1University of Wisconsin-Madison Medical School.

Nutrition Reviews
|December 1, 1994
PubMed
Summary

Reduced serotonin (5-hydroxytryptamine or 5HT) activity may contribute to bulimia nervosa and binge eating. This review examines the role of 5HT in feeding behaviors and its connection to other conditions like depression.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Endocrinology

Background:

  • Serotonin (5HT) is a key neuromodulator influencing feeding behaviors.
  • Experimental data shows reduced 5HT activity increases food intake, while increased activity decreases it.
  • Women with bulimia nervosa often exhibit signs of diminished 5HT activity.

Purpose of the Study:

  • To review evidence linking reduced central nervous system 5HT activity to the pathophysiology of bulimia nervosa.
  • To explore the relationship between 5HT disturbances and other psychopathological conditions associated with bulimia nervosa.

Main Methods:

  • Literature review of studies investigating serotonin's role in feeding.
  • Analysis of research on 5HT activity in women with bulimia nervosa.
  • Examination of the comorbidity of bulimia nervosa with depression, substance abuse, and impulsivity.

Main Results:

  • Experimental reduction of 5HT activity in animals leads to increased food intake.
  • Increased 5HT activity experimentally results in decreased food intake.
  • Evidence suggests a potential role for reduced 5HT activity in the binge eating characteristic of bulimia nervosa.

Conclusions:

  • Reduced central nervous system 5HT activity is a plausible factor in the development of bulimia nervosa.
  • Serotonin system dysfunction may be interconnected with other psychiatric issues seen in bulimia nervosa, including depression, substance abuse, and impulsivity.

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