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Related Experiment Videos

Lidocaine overdose: another preventable case?

J Gonzalez del Rey1, S Wason, R W Druckenbrod

  • 1Division of Emergency Medicine, Children's Hospital Medical Center, Cincinnati, OH 45229.

Pediatric Emergency Care
|December 1, 1994
PubMed
Summary
This summary is machine-generated.

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Viscous lidocaine poses overdose risks in children due to altered pharmacokinetics. Benzocaine is a safer alternative for pediatric mouth lesions, but careful dosing instructions are crucial if lidocaine is used.

Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Toxicology

Background:

  • Viscous lidocaine is frequently prescribed for painful oral conditions in children.
  • Pediatric patients exhibit altered pharmacokinetics compared to adults, affecting drug metabolism and elimination.
  • Adult dosing of lidocaine may lead to toxic levels in pediatric populations.

Observation:

  • Pediatric patients have increased absorption, decreased clearance, and prolonged half-life of lidocaine.
  • Doses safe for adults can be hazardous for children, increasing overdose risk.
  • Lidocaine use for pediatric mouth lesions lacks sufficient safety data.

Findings:

  • Altered pharmacokinetics in children present a significant toxic hazard with standard lidocaine doses.
  • Benzocaine demonstrates a low incidence of side effects, making it a safer alternative for infants and children.

Related Experiment Videos

  • Specific, clear administration instructions are vital if lidocaine is prescribed, avoiding PRN orders.

    • Implications:

    • Healthcare providers should exercise extreme caution when prescribing viscous lidocaine to pediatric patients.
    • Benzocaine should be considered as a primary alternative for treating painful mouth lesions in children.
    • Strict adherence to precise dosing, frequency, and administration guidelines is essential to mitigate risks associated with lidocaine use in pediatrics.