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Interferon-gamma, an anti-fibrogenic cytokine which binds to heparan sulfate
H Lortat-Jacob1, P Esterre, J A Grimaud
1Unité de Physiopathologie Cellulaire et Moléculaire des Fibroses Tissulaires-CNRS URA 1459, Institut Pasteur de Lyon, France.
Interferon-gamma is a T cell secreted cytokine. It has a great number of biological activities, among which is the down regulation of collagen molecules. IFN-gamma acts through cell surface receptors, but also binds to heparan sulfate proteoglycans. In vivo, it is postulated that the heparan sulfate/IFN-gamma interaction can modulate the activity and availability of the cytokine.
Interferon-gamma is a T cell secreted cytokine. It has a great number of biological activities, among which is the down regulation of collagen molecules. IFN-gamma acts through cell surface receptors, but also binds to heparan sulfate proteoglycans. In vivo, it is postulated that the heparan sulfate/IFN-gamma interaction can modulate the activity and availability of the cytokine.