[Neuromediator bioamines in the histogenesis of corpora lutea]

The role of neuromediator bioamines in histogenesis of corpora lutea was under study. Cryostate slices of ovaries from 27 cats were treated after A. Bjorklund's fluorescent histochemical method modified by V. N. Shvalev and N. I. Zhuchkova. The content of serotonin and catecholamines was measured cytospectrofluorometrically in varicose dilatations and intervaricose sites of perivascular plexuses and terminals, in membranous and parenchymatous macrophages of corpus luteum. A reliably increased content of the examined neuromediators was found in all the tested nervous structures at the stage of glandular metamorphosis and corpus luteum maturity. Serotonin and catecholamines are believed to be needed for glandular metamorphosis and corpus luteum maturation. A higher level of catecholamines at the stage of corpora lutea maturity in comparison with serotonin may be explained by an activating effect of these neuromediators on progesterone synthesis. Catecholamines may be necessary for luteolithic action of prostaglandins. Macrophages seem to inactivate mediator excess.