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[Myeloma with intrathoracic tumor expression]

J F Bervar1, I Tillie-Leblond, T Facon

  • 1Service de Pneumologie, Hôpital Calmette, CHRU de Lille.

Revue Des Maladies Respiratoires
|January 1, 1995
PubMed
Summary

This case study details a rare presentation of multiple myeloma, a cancer of plasma cells, involving unusual thoracic and orbital tumors. Despite treatment, the prognosis for this aggressive cancer remains poor.

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Area of Science:

  • Oncology
  • Hematology
  • Ophthalmology

Background:

  • Multiple myeloma typically presents with bone lesions, but can manifest with extramedullary plasmacytomas.
  • Intrathoracic and orbital plasmacytomas are rare presentations of multiple myeloma.

Observation:

  • A 58-year-old patient presented with a left apical opacity, general health decline, ophthalmic disease, and frontal syndrome.
  • Radiological imaging revealed tumors originating from the first rib, skull base, and frontal area, with cranial vault lacunae.
  • Laboratory findings included hyperproteinemia, IgG gamma monoclonal gammopathy, and medullary plasmacytosis with atypical plasma cells.

Findings:

  • Diagnosis of multiple myeloma with plasmacytoma of the rib and retro-orbital area.
  • The patient exhibited rare intrathoracic and orbital involvement, distinct from typical osteolytic lesions.

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Implications:

  • This case highlights the diverse and rare clinical manifestations of multiple myeloma.
  • Early recognition of unusual presentations is crucial for timely diagnosis and management.
  • Despite potential treatment responses, the overall prognosis for extensive or rare myeloma presentations remains challenging.