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Related Experiment Videos

Retinal pathologic changes in multiple sclerosis

J B Kerrison1, T Flynn, W R Green

  • 1Eye Pathology Laboratory, Wilmer Ophthalmological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland.

Retina (Philadelphia, Pa.)
|January 1, 1994
PubMed
Summary
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Multiple sclerosis (MS) can cause ocular inflammation, including uveitis and retinal phlebitis. Trypsin digestion is a sensitive method for detecting retinal phlebitis in MS patients.

Area of Science:

  • Ophthalmology
  • Neurology
  • Pathology

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
  • Ocular manifestations are common in MS, affecting various parts of the eye.

Purpose of the Study:

  • To detail the ocular pathological changes in multiple sclerosis (MS).
  • To specifically investigate the effects of MS on the uveal tract and retinal veins.

Main Methods:

  • Review of 26 MS patients and 3 neuromyelitis optica patients.
  • Retinal trypsin digestion performed on 20 MS patients.
  • Microscopic examination for ocular inflammation and atrophy.

Main Results:

  • 73% of MS cases showed nerve fiber and ganglion cell layer atrophy, correlating with optic nerve atrophy.

Related Experiment Videos

  • Choroiditis (11.5%) and retinal phlebitis (20%) were observed.
  • Retinal phlebitis was often identified only after trypsin digestion.

    • Conclusions:

    • Uveitis and retinal phlebitis are significant ocular manifestations of MS.
    • Trypsin digestion is a sensitive technique for diagnosing retinal phlebitis in MS.
    • Ocular lesions in MS resemble CNS perivenular cuffing.