[Changes in myocardial function in patients with acute leukemias under the influence of rubomycin]

Physical electro- and echocardiographic methods were used to study myocardial function in 70 patients with acute leukemia (AL). 40% of them in the primary active phase had hypokinetic, while 60% hyperkinetic circulation. Leucocytosis and thrombocytopenia proved prognostically unfavorable for myocardium condition. Cardiotoxic rubomycin doses have been established. Pathogenic mechanisms underlying deterioration of myocardial contractility, reduction of stroke volume and rearrangement of central hemodynamics are considered. Administration of riboxin with finoptine promoted normalization of clinical and improvement of echo-CG sings of myocardiopathy in patients given total rubomycin doses 200-450 mg/m2.