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[Anthelmintic resistance in sheep nematodes in The Netherlands]
F H Borgsteede1, J J Pekelder, D P Dercksen
1DLO-Instituut voor Veehouderij en Diergezondheid (ID-DLO), Lelystad.
Tijdschrift Voor Diergeneeskunde
|March 15, 1995
Summary
Anthelmintic resistance in sheep nematodes is widespread in the Netherlands, with benzimidazole resistance confirmed on most farms. Further testing revealed no significant resistance to ivermectin or levamisole treatments.
Area of Science:
- Veterinary Parasitology
- Sheep Health Management
- Anthelmintic Resistance
Context:
- Investigated anthelmintic resistance in sheep nematodes across 71 Dutch farms in 1994.
- Utilized faecal egg count reduction tests (FECRT) and egg hatch assays (EHA) for resistance detection.
- Evaluated resistance to benzimidazoles (oxfendazole), ivermectin, and levamisole.
Purpose:
- To determine the prevalence of anthelmintic resistance in sheep nematodes in the Netherlands.
- To identify specific nematode species exhibiting resistance to common anthelmintics.
- To validate FECRT and EHA findings for resistance assessment.
Summary:
- Benzimidazole resistance was prevalent, confirmed by FECRT on 56 farms and EHA (ED50 > 0.12 µg/mL thiabendazole on 59 farms).
- Resistance was observed in Haemonchus contortus, Cooperia curticei, Ostertagia spp., and/or Trichostrongylus spp.
- No significant resistance was detected for ivermectin and levamisole.
Impact:
- Highlights the significant challenge of benzimidazole resistance in Dutch sheep farming.
- Provides crucial data for developing effective parasite control strategies.
- Informs veterinary recommendations for anthelmintic drug selection and rotation.