Duration and magnitude of ST-segment depression during exercise and recovery: a symmetric relation

The pattern of appearance and disappearance of ST depression on 12-lead electrocardiographic exercise testing in subjects with coronary artery disease (> or = 70% stenosis) and its relation to the severity of disease were prospectively explored in 34 consecutive patients. The first lead to show positivity during exercise also developed maximum ST depression in 73% of patients and was the last lead to lose positivity in recovery (94%). The last lead to show positivity during exercise was first to lose positivity in recovery (92%). Greater ST depression was associated with a greater number of positive leads (p < 0.001; r = 0.7). The duration of ST depression during exercise, maximum ST depression, and recovery time were related (p = 0.001, r = 0.6; p = 0.006, r = 0.5; p < 0.001, r = 0.6, respectively, for the three interactions). However, the correlations of ST depression and recovery time with the severity of vessel disease and with rate-pressure product at initial ST depression were poor, suggesting that the degree of ST-segment depression and recovery time may depend more on the duration and intensity of myocardial ischemia solicited with exercise rather than on the ischemic threshold or on the severity of coronary artery disease.