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Related Experiment Videos

Training increases collateral-dependent muscle blood flow in aged rats

H T Yang1, R W Ogilvie, R L Terjung

  • 1Department of Physiology, State University of New York, Syracuse 13210.

The American Journal of Physiology
|March 1, 1995
PubMed
Summary

Physical training significantly improved blood flow to the hindlimbs of aged rats with blocked arteries. This enhanced blood flow (BF) to muscles may help prevent issues like intermittent claudication.

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Area of Science:

  • Physiology
  • Exercise Science
  • Vascular Biology

Background:

  • Peripheral artery disease (PAD) affects blood flow, particularly in the limbs.
  • Aging can exacerbate vascular dysfunction and reduce exercise capacity.
  • Collateral circulation is crucial for blood supply when major arteries are compromised.

Purpose of the Study:

  • To investigate the efficacy of physical training in enhancing collateral-dependent hindlimb blood flow (BF) in aged male rats.
  • To assess the impact of training on muscle force maintenance in the context of reduced arterial flow.

Main Methods:

  • Aged male rats underwent femoral artery ligation to induce collateral-dependent BF.
  • One group engaged in mild-intensity treadmill training, while a control group remained sedentary.

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  • Blood flow was measured using microspheres, and muscle force was assessed via isometric contractions.

    • Main Results:

    • Trained rats exhibited significantly improved exercise tolerance compared to sedentary controls.
    • Trained rats demonstrated superior maintenance of muscle tension during high-frequency contractions.
    • Overall hindlimb BF was 43% greater in trained rats, with a ~78% increase in distal limb muscles.

    Conclusions:

    • Mild-intensity physical training effectively enhances collateral-dependent blood flow in aged rats with compromised limb circulation.
    • Training improves muscle functional capacity under conditions of arterial insufficiency.
    • These findings suggest physical training as a potential intervention for conditions like intermittent claudication.