Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-induced parotitis

D F Thompson1

  • 1Department of Pharmacy Practice, Southwestern Oklahoma State University, Weatherford 73096.

Journal of Clinical Pharmacy and Therapeutics
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

Drug-induced parotitis is rare, often linked to phenylbutazone, oxyphenbutazone, and antipsychotics like thioridazine. Anticholinergic effects may predispose patients to parotid gland infections, but evidence for other drug classes is insufficient.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification and Etiology of Visible Quiescent Infections of Monilinia fructicola and Botrytis cinerea in Sweet Cherry Fruit.

Plant disease·2019
Same author

Prophylaxis of migraine headaches with riboflavin: A systematic review.

Journal of clinical pharmacy and therapeutics·2017
Same author

Systematic review of topical amitriptyline for the treatment of neuropathic pain.

Journal of clinical pharmacy and therapeutics·2015
Same author

Psychopathy: clinical features, developmental basis and therapeutic challenges.

Journal of clinical pharmacy and therapeutics·2014
Same author

Retinoic acid syndrome: a review.

Journal of clinical pharmacy and therapeutics·2008
Same author

Prussian blue for treatment of radiocesium poisoning.

Pharmacotherapy·2001
Same journal

Impact of pharmacist-initiated educational interventions on improving medication reconciliation practice in geriatric inpatients during hospital admission in Vietnam.

Journal of clinical pharmacy and therapeutics·2022
Same journal

Evaluation of off-label anti-vascular endothelial growth factor and steroid implant medication uses in macular edema due to retinal vein occlusion in Turkey.

Journal of clinical pharmacy and therapeutics·2022
Same journal

A descriptive analysis of pharmacological management of aggression and/or agitation in patients with traumatic brain injury in a Southwest Virginia inpatient population.

Journal of clinical pharmacy and therapeutics·2022
Same journal

Effects of caregiver counselling on medication persistence and adherence in patients with dementia at a pharmacist-managed clinic: A pilot study.

Journal of clinical pharmacy and therapeutics·2022
Same journal

The 50% and 95% effective doses of remimazolam tosilate with adjuvant sufentanil for sedation in patients with liver cirrhosis undergoing oesophagogastric varices screening endoscopy.

Journal of clinical pharmacy and therapeutics·2022
Same journal

Tumour necrosis factor inhibitor combined with intravenous immunoglobulin and heparin for treatment of recurrent spontaneous abortion: A two-centre, retrospective, cohort study.

Journal of clinical pharmacy and therapeutics·2022
See all related articles

Area of Science:

  • Pharmacology
  • Adverse Drug Reactions
  • Otolaryngology

Background:

  • Drug-induced parotitis is an uncommon adverse drug reaction.
  • Existing data primarily consists of isolated case reports, with limited rechallenge studies to confirm causality.
  • Anticholinergic effects, such as oral drying, are frequently cited as a predisposing factor for parotid gland infections.

Purpose of the Study:

  • To review the literature on drug-induced parotitis.
  • To identify drugs with a significant association with parotitis.
  • To assess the evidence linking various drug classes to parotitis.

Main Methods:

  • Literature review of case reports and studies on drug-induced parotitis.
  • Analysis of reported associations between specific drugs and parotid gland inflammation.

Related Experiment Videos

  • Evaluation of evidence for drug rechallenge in confirmed cases.

    • Main Results:

    • Phenylbutazone and oxyphenbutazone have a notable number of reports implicating them in causing parotitis.
    • Antipsychotics, particularly thioridazine, are associated with parotitis, often linked to anticholinergic side effects.
    • Insufficient literature exists to link histamine (H2) receptor blockers, interferon-alpha, doxycycline, trimipramine, nifedipine, methyldopa, nitrofurantoin, nicardipine, isoproterenol, or ritodrine to parotitis.

    Conclusions:

    • Phenylbutazone, oxyphenbutazone, and thioridazine are drugs of concern for causing parotitis.
    • Anticholinergic properties may play a role in the pathogenesis of drug-induced parotitis.
    • Further research is needed to establish or refute the link between other drug classes and parotitis.