Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serotonergic functions in man

T N Chase, I Shoulson, A C Carter

    Monographs in Neural Sciences
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    This study investigated serotonin

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nanokelvin DC and AC Meissner-transition-edge temperature detectors.

    The Review of scientific instruments·2019
    Same author

    Wideband infrared trap detector based upon doped silicon photocurrent devices.

    Applied optics·2018
    Same author

    Factors related to genetic testing in adults at risk for Huntington disease: the prospective Huntington at-risk observational study (PHAROS).

    Clinical genetics·2016
    Same author

    HDQLIFE: development and assessment of health-related quality of life in Huntington disease (HD).

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2016
    Same author

    Preventing or repairing ileal conduit herniation?

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2014
    Same author

    Experimental measurements and noise analysis of a cryogenic radiometer.

    The Review of scientific instruments·2014
    Same journal

    Neurobiology of drug abuse.

    Monographs in neural sciences·1987
    Same journal

    Neurophysiological and neuropharmacological effects of opiates.

    Monographs in neural sciences·1987
    Same journal

    Neurobiology of phencyclidine.

    Monographs in neural sciences·1987
    Same journal

    Neuropharmacology of cocaine: role of monoaminergic systems.

    Monographs in neural sciences·1987
    Same journal

    Neurophysiological effects of opiates in the CNS.

    Monographs in neural sciences·1987
    Same journal

    Serotonergic mechanisms of hallucinogenic drug effects.

    Monographs in neural sciences·1987
    See all related articles

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Preclinical studies suggest serotonin systems regulate motor and neuroendocrine functions.
    • Human studies are needed to confirm these roles.

    Purpose of the Study:

    • To examine the role of serotonin in regulating extrapyramidal and neuroendocrine functions in humans.
    • To assess the effects of serotonergic drugs on neurological disorders.

    Main Methods:

    • Administered drugs affecting serotonin (L-tryptophan, parachlorophenylalanine, L-5-hydroxytryptophan, fenfluramine) to patients with neurological disorders.
    • Monitored extrapyramidal signs and plasma prolactin levels.

    Main Results:

    • L-tryptophan and parachlorophenylalanine did not consistently alter extrapyramidal signs in parkinsonism or Huntington's disease.

    Related Experiment Videos

  • L-5-hydroxytryptophan worsened parkinsonian symptoms (akinesia, rigidity).
  • Fenfluramine did not affect involuntary movements in Huntington's chorea but increased prolactin levels.

    • Conclusions:

    • Serotonergic manipulation has complex effects on human neurological and neuroendocrine functions.
    • L-5-hydroxytryptophan may exacerbate motor deficits in Parkinson's disease.
    • Fenfluramine's effect on prolactin suggests a role in neuroendocrine regulation.