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Updated: Jul 31, 2026
04:48
Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))
Published on: May 4, 2020
Brain iron: location and function
J L Beard1, J D Connor, B C Jones
1Nutrition Department, Pennsylvania State University 16802.
Progress in Food & Nutrition Science
|July 1, 1993
Summary
This review examines iron distribution and function in the human brain, highlighting how iron status impacts neural development, neurotransmitter metabolism, and cognition.
Area of Science:
- Neuroscience
- Biochemistry
- Human Physiology
Background:
- Iron is essential for numerous brain functions.
- Dysregulation of iron homeostasis is implicated in neurological disorders.
Purpose of the Study:
- To review the distribution and function of iron in the human brain.
- To explore the role of iron in neural development, neurotransmitter metabolism, and cognition.
- To discuss findings from appropriate animal models.
Main Methods:
- Literature review of studies on iron in the human brain.
- Analysis of data concerning iron status abnormalities.
- Examination of animal models for iron metabolism research.
Main Results:
- Iron distribution varies across different brain regions.
- Abnormal iron levels affect neurotransmitter synthesis and signaling.
- Altered iron status is linked to cognitive impairments and developmental issues.
Conclusions:
- Iron is critical for optimal brain function throughout the lifespan.
- Maintaining iron homeostasis is vital for neurological health.
- Further research in animal models can elucidate iron's role in brain disorders.
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