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Concentric left ventricular hypertrophy in patients with Takayasu arteritis
Y Hashimoto1, T Oniki, E Kaneko
1Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Japan.
Angiology
|November 1, 1993
Summary
Takayasu arteritis (TA) patients with severe aortic regurgitation (AR) exhibit concentric left ventricular hypertrophy (LVH). This LVH pattern in TA is linked to pressure overload, not just aortic valve issues.
Area of Science:
- Cardiology
- Cardiovascular Imaging
- Rheumatology
Background:
- Aortic regurgitation (AR) in Takayasu arteritis (TA) is typically attributed to aortic ring dilation or cusp thickening.
- The specific pattern of left ventricular hypertrophy (LVH) in TA patients with AR remains undescribed.
Purpose of the Study:
- To investigate and describe the left ventricular (LV) geometry in patients with TA, particularly those with severe AR.
- To differentiate LVH patterns in TA patients from those with isolated severe AR.
Main Methods:
- Evaluated 22 patients with TA and severe AR (group 1), 10 with TA and systemic hypertension (group 2), and 17 with isolated severe AR (group 3).
- Utilized M-mode echocardiography to assess LV dimensions and wall thickness.
- Calculated the concentric hypertrophic ratio (CHR) to quantify LVH patterns.
Main Results:
- Patients with TA (groups 1 and 2) had smaller LV dimensions compared to the isolated AR group (group 3).
- Group 1 (TA with AR) showed greater LV wall thickness than group 3.
- The concentric hypertrophic ratio (CHR) was significantly higher in groups 1 and 2 compared to group 3, indicating concentric LVH.
Conclusions:
- Patients with Takayasu arteritis demonstrate concentric left ventricular hypertrophy, indicative of pressure overload.
- This finding holds true even when TA is complicated by severe aortic regurgitation.
- The study clarifies the cardiac remodeling pattern in TA, contributing to a better understanding of its cardiovascular manifestations.