Viral immunopathology of human tumors

Virally induced tumors provide the strongest case of host surveillance against neoplastic cells and their precursors. Human cancers associated with Epstein-Barr virus, hepatitis B virus, papilloma virus and human T cell leukemia virus infection are responsible for approximately 15-20% of the total incidence of cancer world-wide. Current work in each of these virus/tumor systems seeks to understand the mechanisms of viral action and to identify strategies of immune intervention that may allow us to prevent viral infection or to control its potentially life-threatening consequences.