Urinary protein excretion and the diagnosis of graft rejection or renal dysfunction in renal transplant patients
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Updated: Aug 5, 2026

Murine Renal Transplantation Procedure
Published on: July 10, 2009
M Hossein-Nia1, G J Mellotte, P Foxall
1Department of Cardiological Sciences, St George's Hospital Medical School, London, UK.
Abstract:
Urinary proteins have been found to be a sensitive marker of renal damage caused by nephrotoxic agents. An electrophoretic method was used to investigate the potential value of the pattern of urinary protein excretion in 14 cyclosporin-treated renal transplant patients, to differentiate between graft rejection episodes and other causes of renal dysfunction. Urinary protein excretion consistent with renal damage was observed in all of the patients studied, with no marked differences between those with signs of graft rejection, those with renal dysfunction, or those with stable renal function.
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