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Corticosteroids and growth

R N Fine1

  • 1Department of Pediatrics, Childrens Medical Center, State University of New York at Stony Brook.

Kidney International. Supplement
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Corticosteroids inhibit growth by affecting growth factors like growth hormone (GH) and insulin-like growth factor-I (IGF-I). Recombinant human growth hormone (rhGH) effectively reverses these growth-suppressing effects.

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Area of Science:

  • Endocrinology
  • Pediatric Growth and Development

Background:

  • Corticosteroids are known to suppress linear growth in children.
  • This growth suppression is linked to disruptions in key growth factors.

Purpose of the Study:

  • To elucidate the mechanisms by which corticosteroids inhibit growth.
  • To evaluate the efficacy of recombinant human growth hormone (rhGH) in counteracting corticosteroid-induced growth suppression.

Main Methods:

  • Investigated the impact of corticosteroids on spontaneous and stimulated growth hormone (GH) secretion.
  • Assessed the effects on local insulin-like growth factor-I (IGF-I) production.
  • Examined the role of somatostatin in corticosteroid-mediated GH suppression.
  • Evaluated the anabolic and catabolic effects of corticosteroids.

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Main Results:

  • Corticosteroids were found to suppress linear growth through abnormal GH secretion and reduced IGF-I production.
  • GH responses were blunted due to alterations in somatostatin.
  • Corticosteroids exhibited anti-anabolic properties, leading to protein wasting.
  • Exogenous rhGH administration effectively reversed the catabolic effects of corticosteroids.

Conclusions:

  • Corticosteroids inhibit linear growth by disrupting growth factor signaling pathways.
  • rhGH can overcome the growth-suppressive effects of both corticosteroids and uremia.