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Reproduction and the APUD system

I E Wanke1

  • 1Department of Medicine, University of Calgary, Alberta, Canada.

Seminars in Surgical Oncology
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

The amine precursor uptake decarboxylase (APUD) system

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Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Oncology

Background:

  • The amine precursor uptake decarboxylase (APUD) system's role in the reproductive tract is not well-defined.
  • Evidence primarily shows neuroendocrine cells in the prostate and cervix.
  • The specific biological function and products of APUD cells in these tissues are yet to be discovered.

Purpose of the Study:

  • To review the current evidence for the APUD system in the human reproductive tract.
  • To highlight the presence and potential roles of APUD cells and tumors in reproductive tissues.
  • To underscore the need for further research into the function and therapeutic strategies for APUD-related reproductive tumors.

Main Methods:

  • Literature review of studies documenting APUD cells in reproductive tissues.

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  • Analysis of existing data on the characteristics and behavior of APUD-cell-related tumors.
  • Synthesis of information regarding the known and suspected functions of the APUD system in the reproductive tract.

    • Main Results:

    • The APUD system's involvement in the normal reproductive tract is mainly observed in the prostate and cervix.
    • Neuroendocrine cells with APUD characteristics are present in various reproductive tissues, including the endometrium, ovary, and testes.
    • Tumors arising from these tissues often exhibit aggressive behavior.

    Conclusions:

    • The APUD system likely plays a role in the prostate, though its exact function requires elucidation.
    • APUD-cell-like tumors are found across multiple reproductive organs and are typically aggressive.
    • Optimal therapeutic approaches for these aggressive reproductive tumors remain to be determined.