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The D2 autoreceptor agonists SND 919 and PD 128483 decrease stereotypy in developing rats

M Y Lin1, D E Walters

  • 1Department of Pharmacal Sciences, Auburn University School of Pharmacy, Alabama 36849-5503.

Life Sciences
|January 1, 1994
PubMed
Summary
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Dopamine D2 autoreceptor agonists SND 919 and PD 128483 effectively reduced stereotyped behavior in developing rats by 21 days of age, but not in 10-day-old rats, indicating functional autoreceptor regulation emerges during this period.

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Pharmacology

Background:

  • Dopamine (DA) D2 autoreceptors regulate stereotyped behavior in adult rats.
  • Previous studies failed to show D2 autoreceptor regulation of stereotypy in developing rats.

Purpose of the Study:

  • To investigate the developmental emergence of dopamine D2 autoreceptor-mediated regulation of spontaneous stereotyped behavior in rats.
  • To determine the age at which D2 autoreceptor regulation becomes functional.

Main Methods:

  • Administration of selective D2 autoreceptor agonists (SND 919, PD 128483) to rats of different ages (10, 21, 35 days, and adults).
  • Measurement of spontaneous stereotyped behavior counts.
  • Comparison of agonist effects with haloperidol pretreatment.

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Main Results:

  • SND 919 and PD 128483 significantly decreased stereotypy in 21-day-old, 35-day-old, and adult rats in a dose-dependent manner.
  • No significant effect on stereotypy was observed in 10-day-old rats.
  • Agonist effects were distinct from those of haloperidol, suggesting specific D2 autoreceptor involvement.

Conclusions:

  • Dopamine D2 autoreceptor-mediated regulation of spontaneous stereotyped behavior is functional by 21 days of age in rats.
  • This regulatory mechanism is not yet established at 10 days of age, highlighting a critical developmental window.