Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The dermal dendrocyte]

E Hoyo1, J Kanitakis, D Schmitt

  • 1INSERM U.346, Laboratoire d'Anatomie Pathologique, Hôpital Ed. Herriot, Lyon, France.

Pathologie-Biologie
|September 1, 1993
PubMed
Summary

Recently identified dermal dendrocytes, expressing coagulation factor XIIIa (fXIIIa), are bone-marrow-derived skin cells distinct from Langerhans cells. Their roles in skin homeostasis, immunity, and disease are under investigation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interoperability and HealthGRID.

Methods of information in medicine·2005
Same author

TGFbeta inhibits CD1d expression on dendritic cells.

The Journal of investigative dermatology·2005
Same author

Moderate skin sensitizers can induce phenotypic changes on in vitro generated dendritic cells.

Toxicology in vitro : an international journal published in association with BIBRA·2004
Same author

Determination of sunscreen immune protection factors using human dendritic cell suspensions.

Toxicology in vitro : an international journal published in association with BIBRA·2004
Same author

Novel protein kinase C and matrix metalloproteinase inhibitors of vegetable origin as potential modulators of Langerhans cell migration following hapten-induced sensitization.

International archives of allergy and immunology·2004
Same author

Bed-rest studies for the International Space Station.

ESA bulletin. Bulletin ASE. European Space Agency·2004

Area of Science:

  • Dermatology
  • Immunology
  • Cell Biology

Context:

  • Dermal dendrocytes are a recently identified population of resident dermal cells.
  • These cells are characterized by the immunohistochemical expression of coagulation factor XIIIa (fXIIIa).
  • They originate from bone marrow and possess unique histoenzymatic and immunohistochemical features.

Purpose:

  • To delineate the distinct characteristics of dermal dendrocytes.
  • To explore their potential functions including antigen presentation, macrophage-like activity, and involvement in dermal homeostasis.
  • To investigate their association with cutaneous tumors, inflammatory dermatoses, and potential as targets for HIV infection.

Summary:

  • Dermal dendrocytes are distinct from epidermal Langerhans cells despite sharing some antigen-presenting cell characteristics.
  • Potential roles include acting as macrophages, antigen-presenting cells, and maintaining dermal macromolecule homeostasis.
  • These cells are implicated in the pathogenesis of skin tumors, inflammatory conditions via cytokine production, and may be susceptible to HIV infection.

Impact:

  • Clarifies the unique identity and features of dermal dendrocytes within the skin.
  • Highlights their potential multifaceted roles in skin physiology and pathology.
  • Suggests avenues for future research into their precise functions in health and disease, including inflammatory dermatoses and HIV infection.

Related Experiment Videos