Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Wellcome Lecture, 1992. Cell cycle control

P Nurse1

  • 1Department of Biochemistry, University of Oxford, U.K.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|September 29, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A diffusion model for the coordination of DNA replication in Schizosaccharomyces pombe.

Scientific reports·2016
Same author

Isolation and characterization of the amino-acid pools located within the cytoplasm and vacuoles of Candida utilis.

Planta·2014
Same author

High-frequency transformation of the fission yeast Schizosaccharomyces pombe.

Nature·2012
Same author

Stochastic hybrid modeling of DNA replication across a complete genome.

Proceedings of the National Academy of Sciences of the United States of America·2008
Same author

Cancer research: joint planning for the future.

Annals of oncology : official journal of the European Society for Medical Oncology·2003
Same author

Controlling S-phase onset in fission yeast.

Cold Spring Harbor symposia on quantitative biology·2003
Same journal

The microlandscapes of tree trunks: the effect of lichen and tree-level characteristics on arthropod communities.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Centimetre-scale landscapes to assess the motion behaviour and cognition of gastropods and bivalves.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Intertidal microcosms of wave-swept rocky shores: ecological and physiological insights from a uniquely stressful environment.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Temporal and spatial variation in temperature and oxygen at the microscale: key niche axes for aquatic life.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Natural microcosms in ecology: fulfilling the promise of model systems?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Microbe-induced galls and plant defence: metabolite crosstalk in a co-evolutionary battle.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
See all related articles

Fission yeast genetics reveals a regulatory network controlling the eukaryotic cell cycle, activating p34cdc2 protein kinase for M-phase onset. This network is conserved in vertebrate cells, guiding future research on cell division.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Fission yeast serves as a model organism for studying eukaryotic cell cycle regulation.
  • The p34cdc2 protein kinase, encoded by cdc2+, is a key regulator of cell cycle progression.

Purpose of the Study:

  • To investigate the genetic controls governing the eukaryotic cell cycle.
  • To elucidate the regulatory gene network that activates p34cdc2 protein kinase and controls M-phase onset.

Main Methods:

  • Genetic analysis in fission yeast.
  • Identification of regulatory gene networks.

Main Results:

  • A regulatory gene network in fission yeast controls M-phase onset by activating p34cdc2.

Related Experiment Videos

  • The p34cdc2 kinase also couples M-phase to S-phase completion.
  • A similar regulatory network is present in vertebrate cells.

    • Conclusions:

    • Fission yeast genetics provides a powerful tool for understanding cell cycle control.
    • The identified regulatory network and the role of p34cdc2 are conserved across eukaryotes.
    • Future research should focus on S-phase regulation and cell division mechanisms.