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Major histocompatibility complex-encoded antigen processing gene polymorphism in IDDM

P M van Endert1, R S Liblau, S D Patel

  • 1Department of Microbiology, Stanford University School of Medicine, CA 94305-5402.

Diabetes
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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Genetic variations in Transporter Associated with Antigen Processing (TAP) and Large Multifunctional Protease (LMP) genes are not linked to insulin-dependent diabetes mellitus (IDDM) susceptibility. Studies found no association between TAP and LMP gene polymorphisms and IDDM risk in Danish populations.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Endocrinology

Background:

  • Insulin-dependent diabetes mellitus (IDDM) susceptibility is strongly linked to human leukocyte antigen (HLA) class II gene polymorphisms.
  • The potential involvement of nearby genes in IDDM pathogenesis remains under investigation.
  • Transporter Associated with Antigen Processing (TAP) and Large Multifunctional Protease (LMP) genes, located in the HLA class II region, are candidates due to their role in antigen presentation.

Purpose of the Study:

  • To investigate the association between polymorphisms in the LMP2, TAP1, and TAP2 genes and susceptibility to IDDM.
  • To determine if TAP and LMP gene variations contribute to IDDM pathogenesis.

Main Methods:

  • Genomic and coding sequence polymorphisms of LMP2, TAP1, and TAP2 genes were analyzed.

Related Experiment Videos

  • A cohort of 77 Danish IDDM patients and 102 healthy control subjects were studied.
  • Allelic frequencies were compared between patients and controls, and analyzed in relation to HLA DR types.

    • Main Results:

    • No significant differences were observed in TAP1 and LMP2 allele frequencies between IDDM patients and controls.
    • A notable absence of the TAP2 allele B (long form) was found in IDDM patients.
    • Further analysis indicated this absence was likely due to linkage disequilibrium with HLA DR types, not a direct association.

    Conclusions:

    • Polymorphisms in TAP and LMP genes are unlikely to be directly associated with IDDM susceptibility.
    • The observed TAP2 allele pattern is attributed to genetic linkage with HLA loci.
    • This study suggests that TAP and LMP genes do not play a significant role in IDDM pathogenesis through direct genetic association.