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Betahistine hydrochloride in Méniére's disease
Postgraduate Medical Journal
|August 1, 1976
Summary
Betahistine hydrochloride (Serc) significantly improved vertigo, tinnitus, and deafness in Ménière
Area of Science:
- Otolaryngology
- Neurology
- Clinical Pharmacology
Background:
- Ménière's disease is characterized by vertigo, tinnitus, and hearing loss.
- Effective treatments for Ménière's disease symptoms are crucial.
Purpose of the Study:
- To evaluate the efficacy of betahistine hydrochloride (Serc) in managing Ménière's disease.
- To assess the impact of betahistine on vertigo, tinnitus, and deafness.
Main Methods:
- A double-blind, placebo-controlled, cross-over trial involving 22 patients who completed the study.
- Patients received betahistine 32 mg daily or placebo for 16 weeks, with a 4-week pre-treatment period.
- Daily symptom scores were recorded to track changes in vertigo, tinnitus, and deafness.
Main Results:
- Betahistine hydrochloride demonstrated statistically significant improvements in vertigo, tinnitus, and deafness compared to placebo.
- Vertigo symptoms showed the most substantial positive response to betahistine treatment.
- No adverse reactions were reported during the trial.
Conclusions:
- Betahistine hydrochloride (Serc) is an effective treatment for Ménière's disease symptoms.
- The drug offers a favorable safety profile for managing vertigo, tinnitus, and hearing loss associated with the condition.
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