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Updated: Oct 1, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Pulmonary, pleural and pericardial manifestations of rickettsiosis]
Abstract:
The authors report four observations of rickettsioses with R. conori (3 cases) or R. mooseri (1 case) with pericardial, pleural or pulmonary manifestations (2 cases). On this occasion, they recall that diagnosis of rickettsiosis can only be made on precise conditions: compatible clinical syndrome, significantly increasing then decreasing antibodies level, negative bacteriological and viral investigations and effectiveness of particular antibiotics. They also recall the main characteristics of pericardites, pleurisies, and pneumopathies produced by rickettsiae, probably more frequently than previously thought.
Insights
Rickettsioses, infections caused by Rickettsia bacteria, can manifest with serious heart and lung conditions. Accurate diagnosis requires specific clinical and serological evidence, alongside ruling out other infections.
Area of Science:
- Infectious Diseases
- Cardiology
- Pulmonology
Background:
- Rickettsioses are tick-borne bacterial infections with diverse clinical presentations.
- Cardiac and pulmonary involvement in rickettsioses may be underdiagnosed.
Observation:
- Four cases of rickettsioses were observed, including three caused by Rickettsia conori and one by Rickettsia mooseri.
- Two of these cases presented with pericardial, pleural, or pulmonary manifestations.
Findings:
- Diagnosis of rickettsiosis necessitates a compatible clinical picture, specific antibody level changes, negative bacterial/viral tests, and response to antibiotics.
- Rickettsial pericarditis, pleurisy, and pneumonopathy are significant potential complications.
Implications:
- Increased awareness of cardiac and pulmonary manifestations of rickettsioses is crucial for timely diagnosis.
- Clinicians should consider rickettsial infections in patients with unexplained pericarditis, pleurisy, or pneumonia.
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