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Related Experiment Videos

Oncogene patterns in breast and ovarian carcinomas

B Csókay1, J Papp, I Besznyák

  • 1National Institute of Oncology, Budapest, Hungary.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|December 1, 1993
PubMed
Summary

Amplification of the c-erbB-2 oncogene is linked to survival in breast cancer patients. Similar gene amplifications were investigated in ovarian cancers, revealing a correlation between c-erbB-2 amplification and clinical stage.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The c-erbB-2 (Her-2/neu) oncogene plays a role in various cancers.
  • Understanding gene amplification in breast and ovarian cancers can inform prognosis and treatment.

Purpose of the Study:

  • To investigate the correlation between c-erbB-2 oncogene amplification and survival in breast cancer patients.
  • To examine the amplification of c-erbB-2, c-myc, and Ki-ras genes in ovarian carcinomas and their correlation with clinical staging.

Main Methods:

  • Polymerase Chain Reaction (PCR) was used to detect gene amplification in paraffin-embedded breast cancer tissues and fresh ovarian carcinoma samples.
  • Statistical analysis was performed to determine correlations between gene amplification, survival, histopathologic types, nuclear grading, and clinical staging.

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Main Results:

  • A strong correlation was found between c-erbB-2 amplification and survival in breast cancer patients, as well as with histopathologic types and nuclear grading.
  • In ovarian carcinomas, c-erbB-2 amplification occurred in 34% of samples and correlated significantly with clinical staging (P < 0.05).
  • c-myc amplification was detected in 9% of ovarian carcinomas, while Ki-ras amplification was not observed.

Conclusions:

  • c-erbB-2 amplification is a significant prognostic marker in breast cancer.
  • c-erbB-2 amplification is associated with clinical stage in ovarian carcinomas, suggesting a potential role in ovarian cancer progression.