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Interleukin 13 is a B cell stimulating factor

T Defrance¹, P Carayon, G Billian

¹Unité d'Immunologie et Stratégie Vaccinale, Institut Pasteur de Lyon, France.

The Journal of Experimental Medicine

|January 1, 1994

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Human interleukin 13 (IL-13), a cytokine from T cells, influences B cell maturation and immunoglobulin E synthesis. IL-13 may contribute to allergic diseases alongside IL-4.

Area of Science:

Immunology
Molecular Biology

Background:

Interleukin 13 (IL-13) is a novel cytokine identified in activated T cells.
IL-13 inhibits inflammatory cytokine production by monocytes.
The protein encoded by IL-13 cDNA is the human homologue of mouse Th2-product P600.

Purpose of the Study:

To investigate the effects of IL-13 on B cell maturation.
To compare the biological activities of IL-13 with IL-4 on B cells.

Main Methods:

Assessing the expression of CD23/Fc epsilon RII and class II MHC antigens on B cells treated with IL-13.
Evaluating B cell proliferation in response to IL-13 combined with anti-Ig and anti-CD40 antibodies.
Measuring IgE synthesis induced by IL-13.

Main Results:

Related Experiment Videos

IL-13 enhances CD23/Fc epsilon RII and MHC class II antigen expression on resting B cells.
IL-13 stimulates B cell proliferation when combined with anti-Ig and anti-CD40 antibodies.
IL-13 induces immunoglobulin E (IgE) synthesis.

Conclusions:

The biological activities of IL-13 on B cells significantly overlap with those of IL-4.
IL-13 is suggested to be a key factor, along with IL-4, in the pathogenesis of allergic diseases.